|
KMID : 0614720040470020139
|
|
Journal of Korean Medical Association
2004 Volume.47 No. 2 p.139 ~ p.143
|
|
|
Gene Therapy and Molecular Imaging
|
|
정혜선/Chung, Hesson
권익찬/정서영/Kwon, Ick Chan/Jeong, Seo Young
|
|
|
Abstract
|
|
|
G ene therapy is a method to treat diseases by delivering genes into target cells. ii 7P.- eo1-1d , - O4 1´ Ll
Proteins expressed by the delivered genes or the alterations of the gene profile o~}b) ~j ~L}´ a~ ~) o}~ Th-
in and around the target cells provide therapeutic effects. Conventionally, the body
distribution of delivered gene or expressed proteins has been quantified by deter- 714* 70 z L o1% z 14 AL.
mining the concentrations of the materials of interest in each organ at different time TF;0_4 1 ~o~L} IT
points. This procedure requires sacrifice of a lot of experimental animals and is
timeconsuming. In addition, the information on the timedependent changes in a al ,a ? o aOl ; ~o} L
single animal is lost. Molecular imaging technique could potentially provide answers -´T-ti-47f z ~H- L q (1,11(endoge-
to these problems. The molecular imaging refers to a collection of imaging tech- neous) xfYLT $ ~oa~ of
niques that enable realtime observation of genes, proteins, and other molecules
inside a living body. Magnetic, nuclear, and optical imaging techniques are the most 414 ~--V-Ej TOFOI 1 ~a14 zt
widely used ones to study the biomolecular processes. Many newly developed 118:1 iL&I- o ll of o}L 7,101 7} o} 01
imaging markers and reporter genes are available to trace genes by a variety of }7l0 717 ~1 l
L -r_
~ ~ ~~
imaging techniques. Along with the anatomical information that the conventional L 1 1 r Lc L P
imaging techniques supply, information on the changes at the molecular level pro-
vides a deeper understanding on the biological events.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
 
|
|